The two shows on Sunday February 11 take place at the Liverpool Empire and feature a host of local and national talent.
Susan Boyle and Paul Potts, as well as Collabro, Tokio Myers and Attraction will be taking to the stage.
The two shows will also mark the return to the stage of MerseyGirls performer Julia Carlile.
The dancer has been treated at Alder Hey for scoliosis since she was very young.
She underwent surgery earlier this year and said: ‘They’ve stood by me and now I want to do what I can for them.’
The shows will be hosted by Myleene Klass – with all proceeds going to Alder Hey Children’s Charity.
Tickets are priced from £21 and are available from Liverpool Empire Theatre Box Office on 0844 871 3017 and can be booked by clicking here.